Endocytosis pulls Notch apart

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Endocytosis pulls Notch apart

N otch's neighbors are tearing it apart. On page 445, Nichols et al. show that endocytosis of a ligand on one cell pulls apart its Notch receptor on an adjacent cell, leaving behind an activation-susceptible receptor remnant. Dormant Notch on the cell surface must be cleaved into a free intra-cellular domain that can travel to the nucleus to activate gene expression. Three proteases are known t...

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Endocytosis in Notch Signaling Activation

In cell-physiological terms, endocytosis exerts multiple functions, which are only partially known and characterized. At a minimum, it maintains PM homeostasis by counterbalancing the apposition of new membrane (due to exocytosis) and by renewing PM components. More extensively, endocytosis constantly modulates PM composition and takes an active part in a variety of normal and pathological cell...

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Notch Signaling: Endocytosis Makes Delta Signal Better

Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2007

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.1764iti4