منابع مشابه
Endocytosis pulls Notch apart
N otch's neighbors are tearing it apart. On page 445, Nichols et al. show that endocytosis of a ligand on one cell pulls apart its Notch receptor on an adjacent cell, leaving behind an activation-susceptible receptor remnant. Dormant Notch on the cell surface must be cleaved into a free intra-cellular domain that can travel to the nucleus to activate gene expression. Three proteases are known t...
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Sister chromatid cohesion and chromosome condensation are both essential to the successful completion of mitosis. The recent identification and characterization of the yeast Mcd1p/Scc1p protein reveals a previously unsuspected mechanistic link between these processes.
متن کاملEndocytosis in Notch Signaling Activation
In cell-physiological terms, endocytosis exerts multiple functions, which are only partially known and characterized. At a minimum, it maintains PM homeostasis by counterbalancing the apposition of new membrane (due to exocytosis) and by renewing PM components. More extensively, endocytosis constantly modulates PM composition and takes an active part in a variety of normal and pathological cell...
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Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major evolutionary pressure that can affect the establishment of social hierarchies in animals, and individuals' trai...
متن کاملNotch Signaling: Endocytosis Makes Delta Signal Better
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1764iti4